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You are here:Home » Antibodies » Abs to Angiotensin, Angiotensinogen » Anti -AGT (Angiotensinogen, Serpin A8, SERPINA8)

Anti -AGT (Angiotensinogen, Serpin A8, SERPINA8)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
The human AGT gene product, pre-angiotensinogen, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Human pre-angiotensinogen is encoded by two mRNAs that differ only in the length of the 3'-untranslated region due to postulated use of two polyadenylation sites. There may also be alternative initiation codons (nucleotides 40-42 and 67-69). AGT is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.
Catalog #A2294-48Z
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG3,k
Clone No3C10
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant corresponding to aa1-486 from human AGT with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human AGT.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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