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You are here:Home » Antibodies » Antibodies-Enzymes, Angiotensin Converting (ACE) » Anti -Angiotensin Converting Enzyme 2 (ACE-2, ACEH) Ectodomain

Anti -Angiotensin Converting Enzyme 2 (ACE-2, ACEH) Ectodomain


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Angiogensin I Converting Enzyme-2 (ACE-2) is a type I transmembrane zinc protease that
cleaves angiotensins I and II to produce vasodilatory and anti-proliferative peptides. The
balance between ACE-1 and ACE-2 activity is critical for maintaining cardiovascular, renal,
and pulmonary function. ACE-2 isoforms of 75kD and 120kD are differentially expressed
between lung and kidney, respectively, and a shed soluble form is generated by
TACE/ADAM17 mediated cleavage. ACE-2 also functions as the cellular uptake receptor for
the SARS coronoavirus. Within the extracellular domain, human ACE-2 shares 83% aa
sequence identity with mouse and rat ACE-2.
Suitable for use in ELISA, Western Blot, Immunohistochemistry. Other applications not tested.
Catalog #A2295-02S1
Recommended DilutionELISA: 0.5-1.0ug/ml
Western Blot: 2ug/ml
Immunohistochemistry: 25ug/ml
Optimal dilutions to be determined by the researcher.
HybridomaMouse myeloma with B cells obtained from a mouse.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No9H63
FormSupplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenNS0-derived recombinant human ACE-2 aa18-740; Q9BYF1.
SpecificityRecognizes human ACE-2 ectodomain.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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