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You are here:Home » Antibodies » Abs to Serum Proteins » Anti -Angiotensin II (Angiotensin 2, Ang II)

Anti -Angiotensin II (Angiotensin 2, Ang II)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.
Angiotensin I is converted to angiotensin II through removal of two terminal residues by the enzyme Angiotensin- converting enzyme (ACE, or kinase), which is found predominantly in the capillaries of the lung. ACE is actually found all over the body, but has its highest density in the lung due to the high density of capillary beds there. Angiotensin II acts as an endocrine, autocrine/ paracrine, and intracrine hormone. ACE is a target for inactivation by ACE inhibitor drugs, which decrease the rate of angiotensin II production. Angiotensin II increases blood pressure by stimulating the Gq protein in vascular smooth muscle cells (which in turn activates contraction by an IP3-dependent mechanism). ACE inhibitor drugs are major drugs against hypertension.
Catalog #A2295-05A
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsELISA: 1:1,000-1:10,000.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No11C81
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.05% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman angiotensin II, DRVYIHPF coupled to a carrier protein.
SpecificityRecognizes human Angiotensin II. Due to similarity of angiotensin II and III, antibodies react with both angiotensin II and III but not significantly with angiotensin I or angiotensinogen.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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