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You are here:Home » Antibodies » Antibodies-Receptors » Anti -Angiotensin II Type 2 Receptor (AT2)

Anti -Angiotensin II Type 2 Receptor (AT2)


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Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Angiotensin II mediates its action by interacting with membrane receptor, Angiotensin II type 1 receptors. The signal is transmitted via G-proteins that activates a phosphatidylinositol-calcium second messenger system. ATII receptors are integral membrane proteins of ~359-363aa and predicted to contain at least 7 transmembrane domains. The N and C-terminus are predicted to extracellular and cytoplasmic, respectively. Three isoforms of ATII receptors have been cloned. In rat type 1a (359aa) is expressed in the liver kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscles. Rat Type 1b (also known as AT3; 359aa) is found in liver, kidney, and aorta. Type 1c (177aa) has been detected in brain, kidney, liver, spleen and lung.
Catalog #A2295-07T
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:5000 using ECL. Detects ~45kD band.
ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
Optimal dilutions to be determined by the researcher.
Control PeptideA2295-07U: Angiotensin II Type 2 Receptor, Human, Control Peptide (AT2)
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Also AvailableA2295-07S: Angiotensin II Type 2 Receptor (AT2) Pab Rb xHu
Clone TypePolyclonal
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
ImmunogenSynthetic peptide 18aa sequence mapping near the C-terminus of human AT2 (KLH coupled).
SpecificityRecognizes human AT2 receptor. No sequence homology with other G-protein coupled receptors. Species Sequence Homology
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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