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You are here:Home » Antibodies » Abs to Receptors » Anti -Angiotensin II Type 2 Receptor (AT2)

Anti -Angiotensin II Type 2 Receptor (AT2)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
AGTR-2, also known as AT2, is a 7TM protein that belongs to the G protein-coupled receptor family 1. Both AGTR-2 and AGTR1 bind Angiotensin II and function in the control of hemodynamics. In contrast to AGTR1, which promotes vasoconstriction and cell proliferation, AGTR-2 inhibits growth and promotes apoptosis. In addition, Angiotensin II-induced AGTR-2 signaling induces the release of nitric oxide in the heart, kidney, and brain and participates in tissue morphogenesis and repair. Human AGTR-2 shares 92% amino acid sequence identity with mouse and rat AGTR-2.
Catalog #A2295-07T2
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: 25ug/ml, add 10ul to 1-2.5x10e5 cells in <200ul reaction volume.
Optimal dilutions to be determined by the researcher.
HybridomaMouse myeloma cells with B cells obtained from a mouse immunized with HEK293 cells transfected with human Angiotensin II Type 2 receptor (rhAGTR-2; Accession # NP_000677).
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No8H158
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a lyophilized powder in PBS with 5% trehalose. Reconstitute with 0.2ml sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman AGTR-2-transfected cells.
SpecificityRecognizes human AGTR-2. Stains human AGTR-2 transfected cells but not irrelevant transfectants.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAGTR-2


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