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Anti -Angiotensin II Type 2 Receptor (AT2)
Anti -Angiotensin II Type 2 Receptor (AT2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
FC |
|
| AGTR-2, also known as AT2, is a 7TM protein that belongs to the G protein-coupled receptor family 1. Both AGTR-2 and AGTR1 bind Angiotensin II and function in the control of hemodynamics. In contrast to AGTR1, which promotes vasoconstriction and cell proliferation, AGTR-2 inhibits growth and promotes apoptosis. In addition, Angiotensin II-induced AGTR-2 signaling induces the release of nitric oxide in the heart, kidney, and brain and participates in tissue morphogenesis and repair. Human AGTR-2 shares 92% amino acid sequence identity with mouse and rat AGTR-2. | | | Catalog # | A2295-07T2 | | Applications | Suitable for use in Flow Cytometry. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 25ug/ml, add 10ul to 1-2.5x10e5 cells in <200ul reaction volume. | | Optimal dilutions to be determined by the researcher. | | Hybridoma | Mouse myeloma cells with B cells obtained from a mouse immunized with HEK293 cells transfected with human Angiotensin II Type 2 receptor (rhAGTR-2; Accession # NP_000677). | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 8H158 | | Host | Mouse | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a lyophilized powder in PBS with 5% trehalose. Reconstitute with 0.2ml sterile PBS. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Human AGTR-2-transfected cells. | | Specificity | Recognizes human AGTR-2. Stains human AGTR-2 transfected cells but not irrelevant transfectants. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | AGTR-2 |
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