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Abs to Angiotensin, Angiotensinogen
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Anti -Angiotensinogen (AGT, ANHU, SERPINA8)
Anti -Angiotensinogen (AGT, ANHU, SERPINA8)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IP FC |
|
| Angiotensinogen is a precursor of angiotensin-1 and a member of serpin family, expressed by the liver and secreted in plasma. Angiotensinogen contains Angiotensin 1, 2, and 3. In response to lowered blood pressure, remin cleaves Angiotensinogen and produce angiotensin-1 (1). Angiotensin-converting enzyme (ACE) further removes a dipeptide to produce the physiologically active peptide angiotensin-2. Angiotensin-2 is involved in regulating mineral balance and volume of body fluids, while Angiotensin-3 stimulates aldosterone release (2). In human, Angiotensinogen is 118 amino acids long, but its size varies between species. Defects in Angiotensinogen have been linked to renal tubular dygenesis (RTD) and susceptibility to essential hypertension (3). | | | Catalog # | A2295-10F | | Applications | Suitable for use in Flow Cytometry, Western Blot and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:50 | | Western Blot: 1:200,000-1:500,000 | | Immunoprecipitation: 1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H289 | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA. | | Purity | Supernatant | | Immunogen | Synthetic peptide corresponding to residues near N-terminus of human Angiotensinogen. | | Specificity | Recognizes human Angiotensinogen. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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