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You are here:Home » Antibodies » Abs to Annexin » Anti -Annexin A11 (ANX11, ANXA11, Calcyclin-associated Annexin 50, CAP50)

Anti -Annexin A11 (ANX11, ANXA11, Calcyclin-associated Annexin 50, CAP50)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Annexin A11 (ANXA11), also known as Annexin XI, 56K Autoantigen and Calcyclin-associated annexin 50 (CAP50), is a 54.4kD (predicted) member of the Annexin protein family. The Annexins are a family of Calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexin's have a molecular weight of approximately 35-40kD and consist of a unique amino terminal domain followed by a homologous C-terminal core domain containing the calcium-dependent phospholipid-binding sites. The C terminal domain is comprised of four 60-70 amino acid (aa) repeats, known as annexin repeats or an endonexin fold (Annexin A6 contains 8 annexin repeats). The four annexin repeats form a highly -helical, tightly packed disc known as the annexin domain, which binds to phospholipids in the membrane in a calcium-dependent manner. Members of the annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways. Annexin A11 was identified as a 56 kD antigen recognized by sera from patients with autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, or Sjogren's syndrome. Human Annexin A11 shares 93% identity with mouse and 49% identity with rat Annexin A11.
Applications:
Western Blot: An antibody concentration of 1.0ug/ml is recommended.
Optimal dilutions should be determined by each laboratory for each application.
Storage and Stability:
Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile PBS with 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalog #A2295-15K
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS with 5% trehalose. Reconstitute with sterile PBS, 40-50% glycerol. If 0.1ml is used, the concentration will be 1mg/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenE. coli derived recombinant human Annexin A11 (aa1-505)
SpecificityDetects endogenous human, mouse, and rat Annexin A11 on Western Blots. Does not crossreact with recombinant human Annexin A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, or A13 in Western Blots.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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