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You are here:Home » Antibodies » Abs to Annexin » Anti -Annexin A13 (Annexin XIII, ANX13, ANXA13, Intestine Specific Annexin, ISA)

Anti -Annexin A13 (Annexin XIII, ANX13, ANXA13, Intestine Specific Annexin, ISA)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Annexin A13 (ANXA13), also known as Annexin XIII and Intestine-Specific Annexin, is a
member of the Annexin protein family. Two isoforms have been identified resulting from
alternate splicing. Isoform A consists of 316 amino acids and has a predicted molecular weight
of 36kD whereas isoform B is composed of 375 amino acids and has a predicted molecular
weight of 40kD. Annexins are a family of Calcium-dependent phospholipid-binding proteins
that are preferentially located on the cytosolic face of the plasma membrane. The Annexinís
have a molecular weight of approximately 35 to 40kD and consist of a unique amino terminal
domain followed by a homologous C-terminal core domain containing the calcium-dependent
phospholipid-binding sites. The C terminal domain is comprised of four 60-70 amino acid
repeats, known as annexin repeats or an endonexin fold (Annexin A6 contains 8 annexin
repeats). The four annexin repeats form a highly -helical, tightly packed disc known as the
annexin domain, which binds to phospholipids in the membrane in a calcium-dependent
manner. Members of the annexin family play a role in cytoskeletal interactions, phospholipase
inhibition, regulation of cellular growth, and intracellular signal transduction pathways. The
specific function of Annexin A13 has not been determined but it is associated with the plasma
membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes.
Catalog #A2295-15M1
ApplicationsWestern Blot: An antibody concentration of 1.0ug/ml is recommended.
Optimal dilutions should be determined by each laboratory for each application.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile PBS with 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS with 5% trehalose. Reconstitute with sterile PBS, 40-50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenE. coli-derived recombinant human ANXA13 (aa1-316)
SpecificityDetects endogenous human and mouse ANXA13 in Western Blots. Does not crossreact with recombinant human Annexin A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, or A11 in Western Blots.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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