Annexin A1, 1-346aa, Recombinant, Human (Annexin-1, Lipocortin I, Calpactin II,
Chromobindin-9, p35, ANXA1, ANX1, LPC1)
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| Annexin A1, also known as Lipocortin I, belongs to a family of Ca(2+)-dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. It promotes membrane fusion and is also involved in exocytosis. Since Annexin A1 has phospholipase A2 inhibitory activity to bind from two to four calcium ions with high affinity, this protein may have potential anti-inflammatory activity. The detection of this protein by immunocytochemical means reportedly provides a simple, highly sensitive and specific assay for diagnosis of hairy cell leukemia. Recombinant human Annexin A1 protein was expressed in E. coli and purified by using conventional chromatography. | | | Catalog # | A2295-15S | | Molecular Weight | 38.7kD (346aa) | | Amino Acid Sequence | MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK | | PLDETLKKAL TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNAL | | LSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK VLDLELKGDI EKCLTAIVKC | | ATSKPAFFAE KLHQAMKGVG TRHKALIRIM VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN | | Storage and Stability | Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Molecular Weight | 38.7kD | | Source | E. coli | | Purity | ~90% (SDS-PAGE) | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in Tris-HCL, pH 8.0, 100mM sodium chloride, 1mM DTT, 10% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Annexin A1, 1-346aa, Recombinant, Human (Annexin-1, Lipocortin I, Calpactin II, Chromobindin-9, p35, ANXA1, ANX1, LPC1) |
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