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You are here:Home » Antibodies » Abs to Ankyrin » Anti -ANKTM1 (TRPA1, Transient Receptor Potential Cation Channel, subfamily A, Member 1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120, Transient receptor potential cation channel subfamily A member 1)

Anti -ANKTM1 (TRPA1, Transient Receptor Potential Cation Channel, subfamily A, Member 1,
Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120,
Transient receptor potential cation channel subfamily A member 1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH IC IF
Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.
Catalog #A2295-16A
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunofluorescence/Immunocytochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 2ug/ml. Detects a band at ~110kD.
Immunocytochemistry (IF): 1:200
Immunohistochemistry (Paraffin): 1:100-1:250
Immunohistochemistry: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by affinity chromatography
ImmunogenSynthetic peptide corresponding to a region within the N-terminus (residues 1-100) of the human TRPA1 protein [Swiss-Prot#O75762].
SpecificityRecognizes human ANKTM1. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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