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You are here:Home » Antibodies » Abs to Infectious Disease Anthrax » Anti -ANTXR1, phosphorylated (Tyr425) (Anthrax Toxin Receptor 1, Tumor Endothelial Marker 8, ATR, TEM8) (APC)

Anti -ANTXR1, phosphorylated (Tyr425) (Anthrax Toxin Receptor 1, Tumor Endothelial Marker
8, ATR, TEM8) (APC)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Catalog #A2296-97C-APC
ApplicationsSuitable for use in FLISA and Dot Blot. Other applications not tested.
Recommended DilutionFLISA: 1:1,000
Dot Blot: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acid residues surrounding Tyr425 of human ANTXR1 (KLH).
SpecificityRecognizes human ANTXR1 when phosphorylated at Tyr425.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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