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You are here:Home » Antibodies » Abs to Infectious Disease Anthrax » Anti -ANTXR1 (Y382) (Anthrax Toxin Receptor 1, Tumor Endothelial Marker 8, ATR, TEM8) (PE)

Anti -ANTXR1 (Y382) (Anthrax Toxin Receptor 1, Tumor Endothelial Marker 8, ATR, TEM8) (PE)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Catalog #A2296-97D-PE
ApplicationsSuitable for use in FLISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionFLISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months after receipt at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Note Applications are based on unconjugated antibody.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to amino acid residues surrounding Y382 of human ANTXR1 (KLH).
SpecificityRecognizes human ANTXR1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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