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You are here:Home » Biochemicals » Biochem-Antibiotics » Antibiotic UCN-01 (7-Hydroxystaurosporine, UCN-01)

Antibiotic UCN-01 (7-Hydroxystaurosporine, UCN-01)


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Isolated from Streptomyces sp., Antibiotic UCN-01 inhibits protein kinase C (PKC) and cyclin-dependent kinase 2 (CDK2) resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these anti-cancer agents.
Catalog #A2297-39
Solubility Soluble in ethyl ethanol, DMF or DMSO.
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute to nominal volume. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light.
CAS Number112953-11-4
Molecular FormulaC28H26N4O4
Molecular Weight482.5
SourceStreptomyces sp.
Purity98% by HPLC.
FormSupplied as a light tan solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names7-Hydroxystaurosporine, UCN-01

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