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Antibiotic UCN-01 (7-Hydroxystaurosporine, UCN-01)
Antibiotic UCN-01 (7-Hydroxystaurosporine, UCN-01)
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| Isolated from Streptomyces sp., Antibiotic UCN-01 inhibits protein kinase C (PKC) and cyclin-dependent kinase 2 (CDK2) resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these anti-cancer agents. | | | Catalog # | A2297-39 | | Solubility | Soluble in ethyl ethanol, DMF or DMSO. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Reconstitute to nominal volume. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light. | | CAS Number | 112953-11-4 | | Molecular Formula | C28H26N4O4 | | Molecular Weight | 482.5 | | Source | Streptomyces sp. | | Purity | 98% by HPLC. | | Form | Supplied as a light tan solid. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | 7-Hydroxystaurosporine, UCN-01 |
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