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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B IH

AP-2 is a sequence-specific DNA binding transcription factor first identified in mammalian cultured cells. In humans and mice, AP-2 belongs to a gene family that includes two other genes, AP-2b and AP-2.2. The AP-2 family proteins share a novel, highly conserved DNA binding and dimerization domain referred to as a basic helix-span-helix domain in their C-terminal halves, while their N-terminal portions have diverged considerably. AP-2 transcription factors have been suggested to exert key regulatory functions in vertebrate embryonic development, in tumorigenicity of various cancer cell types. The AP-2 gene family also plays a role in the control of cell growth and differentiation in breast cancer.
Catalog #	A2298-59
	Suitable for use in Western Blot Immunohistochemistry (Formalin fixed paraffin embedded sections after microwave treatment.Immunohistochemistry fixative formal saline with calcium paraffin embedded using 10 min microwave treatment).
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	3C106
Host	Mouse
Concentration	~1 mg/ml
Form	Supplied as a liquid in PBS, pH 7.2.
Purity	Purified by Protein A affinity chromatography.
Immunogen	C-terminal peptide of AP-2 alpha.
Specificity	Specific for AP-2
Important Note	This product is intended for research use only, not for use in human, therapeutic or diagnostic applications.