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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -AP-2

Anti -AP-2

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
AP-2 is a sequence-specific DNA binding transcription factor first identified in mammalian cultured cells. In humans and mice, AP-2 belongs to a gene family that includes two other genes, AP-2b and AP-2.2. The AP-2 family proteins share a novel, highly conserved DNA binding and dimerization domain referred to as a basic helix-span-helix domain in their C-terminal halves, while their N-terminal portions have diverged considerably. AP-2 transcription factors have been suggested to exert key regulatory functions in vertebrate embryonic development, in tumorigenicity of various cancer cell types. The AP-2 gene family also plays a role in the control of cell growth and differentiation in breast cancer.
Catalog #A2298-59
Suitable for use in Western Blot Immunohistochemistry (Formalin fixed paraffin embedded sections after microwave treatment.Immunohistochemistry fixative formal saline with calcium paraffin embedded using 10 min microwave treatment).
Clone TypeMonoclonal
IsotypeIgG1
Clone No3C106
HostMouse
Concentration~1 mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenC-terminal peptide of AP-2 alpha.
SpecificitySpecific for AP-2
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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