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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -AP-2 alpha

Anti -AP-2 alpha

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP IH
The sequence-specific transcription factor activator protein 2 alpha (AP-2 alpha) is required for normal growth and morphogenesis during mammalian development (1,2). Decreased or loss of AP-2 alpha expression has been observed in many different types of human cancers including breast cancer (3,4), ovarian cancer (5), melanoma (6) and prostate cancer (7). These findings suggest that AP-2alpha expression plays a crucial role in tumorigenicity. Studies have also shown that p53 overexpression in human breast carcinoma cells induces the level of AP-2 alpha expression. Furthermore, p53 binds to the cis-element in the AP-2alpha promoter, suggesting that AP-2 alpha is a target of p53. AP-2 alpha may mediate the effect of p53 to inhibit cell proliferation (8).
Catalog #A2298-59D
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern blot: 1:1000
Immunoprecipitation: 1:50
Immunohistochemistry (Paraffin): 1:300
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA and 50% glycerol.
PurityPurified by protein A and peptide affinity chromatography
ImmunogenSynthetic peptide (KLH-coupled) derived from a sequence of human AP-2 alpha.
SpecificityDetects endogenous levels of total human AP-2 alpha protein. Species Ccrossreactivity: mouse, rat and monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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