Anti -Ap-2 (Transcription Factor AP-2-alpha, AP2-alpha, AP-2 Transcription Factor,
Activating Enhancer-binding Protein 2-alpha, Activator Protein 2, TFAP2A, AP2TF, TFAP2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
IH |
|
| Human AP-2 alpha is a 52kD retinoic acid-inducible, sequence specific DNA binding transcription factor expressed in neural crest lineages. The protein binds to to a GC-rich recognition sequence present in the cis-regulatory regions of several viral and cellular genes, including the enhancers of SV40, HTLV-1, human metallothionein IIa, and mouse major histocompatibility complex. The gene encoding AP-2 alpha is located on chromosome 6 near the HLA locus. AP-2 alpha is required for multiple processes, including limb, eye, craniofacial, cardiovascular, neural tube, and body wall development respectively. It is required for the early morphogenesis of the lens vesicle. It also modulates the function of Myc as a proliferative agent and also as apoptosis inductor. Other known AP-2 alpha-interacting proteins are the retinoblastoma Rb protein, the Yin Yang 1 factor (YY1), and the transcription factors YB-1 and Sp-1. AP-2 alpha may be a factor in predicting survival in patients suffering from epithelial ovarian cancer. | | | Catalog # | A2298-59G | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 1:5-1:10 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Breast carcinoma | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E17 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Purified | | Immunogen | Synthetic peptide corresponding to the C-terminus of AP-2 alpha. Cellular Localization: Nuclear. | | Specificity | Recognizes human AP-2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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