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You are here:Home » Antibodies » Abs to Apoptosis » Anti -Apaf-1, CT (Apoptosis Protease Activating Factor 1)

Anti -Apaf-1, CT (Apoptosis Protease Activating Factor 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH
Apaf-1 is a cytosolic protein that rests in a latent state until bound by cytochrome c (Apaf-2). The resulting Apaf-1/cytochrome c complex associates with the zymogen form of caspase-9 (Apaf-3) in the presence of dATP or ATP, promoting the autocatalytic activation of caspase-9. This antibody will be useful in studies of the activation of caspases through Apaf-1 and also in metastatic melanomas where Apaf-1 is inactivated which leads to defects in the execution of apoptotic cell death.
Catalog #A2298-64X
Cellular Localization Cytoplasmic
Positive Control Testis
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid (serum) containing sodium azide
PuritySerum
ImmunogenA synthetic peptide derived from C-terminus of human Apaf-1.
SpecificitySpecies Crossreactivity: Cross reacts with mouse and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCED4, KIAA0413


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