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You are here:Home » Antibodies » Abs to Proteins » Anti -APC (Adenomatous Polyposis coli)

Anti -APC (Adenomatous Polyposis coli)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
This gene encodes a tumor suppressor protein that includes among its many intracellular functions one of nuclear export. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Catalog #A2298-70A
Applications
Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Acetone fixed, frozen sections.
Optimal dilution to be determined by the researcher.
Clinical RelevanceDetection of APC mutants from colon cell lines.
Positive ControlColon cell line HCT116, SW480 and SW837 extracts.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No4i295
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS. No preservatives added.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa1-433 of the N-terminal fragment of human APC (Adenomutons Polyposis Coli gene Chr 5q) (coupled to maltose binding protein). Cellular Localization: Cytoplasmic and nuclear.
SpecificityRecognizes the N-terminal region of the human APC protein. Epitope Mapping
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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