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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -APC1, phosphorylated (Ser377) (Anaphase Promoting Complex 1, ANAPC1, Meiotic Checkpoint Regulator, MCPR, TSG24)

Anti -APC1, phosphorylated (Ser377) (Anaphase Promoting Complex 1, ANAPC1, Meiotic
Checkpoint Regulator, MCPR, TSG24)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IF
APC1 is 1 of at least 11 subunits of the anaphase promoting complex (APC), which functions at the metaphase to anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.
Catalog #A2298-70G
Cellular Localization Secreted
ApplicationsSuitable for use in Immunofluorescence, ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
Form0.01% Sodium Azide; 0.15M Sodium chloride, 0.02M Potassium phosphate, pH 7
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: C-SHNQSpPKRHS, corresponding to amino acids 373-382 of Human Apc1.
SpecificitySpecific for human APC1 phosphorylated at S377. Minimal reactivity is expected with the non-phosphorylated form of the protein. Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Rat, bovine and canine (all show 100% identity with immunogen) due to sequence homology. Also expected to crossreact with Mouse (90% identity with immunogen).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAnaphase promoting complex subunit 1, Cyclosome subunit 1, Mitotic checkpoint regulator


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