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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -APC6 (ANAPC6, Anaphase Promoting Complex 6, CDC16)

Anti -APC6 (ANAPC6, Anaphase Promoting Complex 6, CDC16)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IF
APC6 (anaphase-promoting complex subunit 6) is a member of the E3 enzyme family. This protein contains TPR repeats and has a molecular weight of approximately 72kD. The APC6 protein is located at the centrosome and mitotic spindle. This protein is required for core stability in the spindle checkpoint pathway. The APC6 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition and spindle elongation. The APC6 protein comprises one subunit of the anaphase promoting complex including APC1-8 and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1.
Catalog #A2298-72L
SpecificitySpecific for the phosphorylated form of APC6 at the T580 residue. Minimal reactivity is expected with the non-phosphorylated form of the protein.
Phosphorylated: ppThr580
Localization: Nuclear
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 12 months from date of receipt.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in 0.01% Sodium Azide Constituents: 0.15M Sodium chloride, 0.02M Potassium phosphate. pH 7.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to a region between aa575 and 588.
SpecificityRecognizes human Apc6.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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