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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -APC10 (Anaphase Promoting Complex 10, ANAPC10, DKFZP564L0562, DOC1)

Anti -APC10 (Anaphase Promoting Complex 10, ANAPC10, DKFZP564L0562, DOC1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
APC is a ubiquitin ligase which specifically targets mitotic regulatory factors such as Pds 1/Cut 2 and cyclin B. It was found that APC 10/Doc 1 is localized in centrosomes and mitotic spindles throughout mitosis, while it is also localized in kinetochores from prophase to anaphase and in mid body in telophase and cytokinesis. These results strongly support the notion that human APC 10/Doc 1 may be one of the APC core subunits rather than the transiently associated regulatory factor.
Catalog #A2298-72N
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
Form0.01% Sodium Azide; 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: GADPKQLERTG, corresponding to amino acids 10-20 of Human APC10.
SpecificityThis antibody detects a band at about 26kD that corresponds to Apc10. Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (100% identity with immunogen) due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAnaphase Promoting Complex Subunit 10


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