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You are here:Home » Antibodies » Abs to Autophagy » Anti -Atg7 (Autophagy Protein 7, Ubiquitin-activating enzyme E1-like protein, hAGP7, APG7-like, ATG7, APG7L)

Anti -Atg7 (Autophagy Protein 7, Ubiquitin-activating enzyme E1-like protein, hAGP7,
APG7-like, ATG7, APG7L)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH IF
Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy. Subunit: Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. In yeast, ATG7 appears to be required for fusion of peroxisomal and vaculuolar membranes. Belongs to the ATG7 family.
Catalog #A2298-74R
DomainThe C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.
Tissue specificityWidely expressed, especially in kidney, liver, lymph nodes and bone marrow.
ApplicationsSuitable for use in Immunofluorescence and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: 1:200-1:3000
Immunofluorescence: 1:200-1:3000
Optimal dilutions to be determined by the researcher. .
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute by adding sterile 40-50% glycerol, ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.
PuritySerum
ImmunogenSynthetic peptide corresponding to the C-terminal of human APG7 protein conjugated to blue carrier protein. CELLULAR LOCAlizaTION: Cytoplasm (Probable).
SpecificityRecognizes human ATG7. Species crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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