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You are here:Home » Biochemicals » Biochem-Molecular Biology » Aphidicolin

Aphidicolin

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Specifications

Aphidicolin is a tetracyclic diterpene antibiotic isolated from species in several genera of fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties blocking the cell cycle at early S-phase. This property has been used to synchronize cell division and has found use as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibition of selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.
Catalog #A2298-75
Nomenclature 3-a,4-a,5-a,17-a-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol
Melting Point225-233°C
AppearanceSupplied as a white to off-white crystalline powder.
SolubilitySoluble in DMSO (50mg/ml). Also soluble in Ethanol and Methanol.
HandlingWarning! Toxic. Aphidicolin may be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all modes of exposure.
Storage and StabilityLyophilized powder may be stored at 4°C. Lyophilized powder is stable for 12 months as supplied. Reconstitute to nominal volume by adding DMSO, ethanol or methanol. Aliquot and store at -20°C. Reconstituted product is stable for 1-2 months at -20°C. Further dilutions can be made in assay buffer.
Note Aphidicolin extremely hygroscopic. Protect from moisture. Store in tightly sealed vial under inert gas. Warm to RT before opening container.
CAS Number38966-21-1
Molecular FormulaC20H34O4
Molecular Weight338.5
SourceNigrospora oryzae
Purity98%
FormSupplied as a white crystalline powder
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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