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Apicidin (cyclo-L-(2-Amino-8-oxodecanoyl)-L- (N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]Suberoylanilide hydroxamic acid)
Apicidin (cyclo-L-(2-Amino-8-oxodecanoyl)-L-
(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]Suberoylanilide hydroxamic acid)
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| A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 – 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced | | | invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible | | | manner. | | | Catalog # | A2298-79B | | Applications | Suitable for use as a histone deacetylase inhibitor. Other applications have not been tested | | Recommended Dilutions | | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Reconstitute with DMSO or ethanol. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 183506-66-3 | | Molecular Formula | C34H49N5O6 | | Molecular Weight | 623.8 | | Purity | ~95% by HPLC | | | | Concentration | ~50mg/ml | | Form | Supplied as an off-white lyophilized powder. Reconstitute in DMSO or ethanol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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