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You are here:Home » Biochemicals » Biochem-Antibiotics » Apicidin

Apicidin

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Specifications

Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis. A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin.
Catalog #A2298-79B
ApplicationsSuitable for use as a histone deacetylase inhibitor. Other applications have not been tested
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Solubility
Reconstitute in DMSO or ethanol (~50mg/ml).
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute with DMSO or ethanol. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number183506-66-3
Molecular FormulaC34H49N5O6
Molecular Weight623.8
Purity~95% by HPLC
FormSupplied as an off-white lyophilized powder. Reconstitute in DMSO or ethanol (~50mg/ml).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Alternate namesCyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; Cyclo(8-oxo-L-2-aminodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl- D-2-piperidinecarbonyl); Apicidin Ia; OSI 2040


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