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Specifications

Clone Host Grade Applications Polyclonal Sheep Purified IH

Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
Catalog #	A2299-08U
Applications	Suitable for use in RID and Immunohistochemistry. Other applications not tested.
Recommended Dilution	RID: 8ul/cm
	Immunohistochemistry: Frozen
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Sheep
Source	Human
Concentration	Not Determined
Form	Supplied as a liquid in GBS, pH 7.4, 0.1% EACA, 0.01% Benzamidine, 1mM EDTA, 0.09% sodium azide.
Purity	Purified
Immunogen	Human Apolipoprotein A-1 purified from plasma and shown to be homogeneous by SDS-PAGE. Cellular Localization: Secreted
Specificity	Recognizes human Apolipoprotein A-1. A single arc is produced when tested by IEP and 2D-IEP against human plasma. Identity is confirmed by double diffusion (Ouchterlony) vs human plasma and a known anti-human Apolipoprotein A-1. Species Crossreactivity: rabbit and canine. Does not crossreact with rat, equine, mouse, goat, bovine, porcine, feline, guinea pig or chicken.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	APOA1/APOC3 fusion gene, Apolipoprotein A I precursor, Apolipoprotein of high density lipoprotein