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Specifications

Clone Host Grade Applications Polyclonal Goat Affinity Purified E B

Apolipoprotein AI promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein AI is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77aa; an 18aa signal peptide is removed co-translationally and a 6aa propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
Catalog #	A2299-12E
Applications
	Suitable for use in ELISA, Western Blot and Conjugation purposes. Other applications not tested.
Recommended Dilutions	Western Blot: 1:200-1:80,000
	ELISA: 1:200-1:80,000
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Goat
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in 75mM PBS, 75mM sodium chloride, 1mM EDTA, pH 7.2, 0.02% sodium azide
Purity	Purified by immunoaffinity chromatography.
Immunogen	Purified Human Apo AI
Specificity	Recognizes human Apo AI. No cross-reaction with Apo AII, Apo B-100, Apo CI, Apo CII, Apo CIII, and Apo E.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.