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You are here:Home » Antibodies » Abs to Lipoproteins » Anti -Apolipoprotein A-I (Apolipoprotein A-I Precursor, Apolipoprotein AI, Apo AI, Apo A-I, ApoA-I, Apo-AI, Apolipoprotein A1, APOA1, Ltw-1, Lvtw-1, MGC117399)

Anti -Apolipoprotein A-I (Apolipoprotein A-I Precursor, Apolipoprotein AI, Apo AI, Apo
A-I, ApoA-I, Apo-AI, Apolipoprotein A1, APOA1, Ltw-1, Lvtw-1, MGC117399)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E IH IC
Apolipoprotein AI promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein AI is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77aa; an 18aa signal peptide is removed co-translationally and a 6aa propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
Catalog #A2299-12P
ApplicationsSuitable for use in ELISA, Dot Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1000; use on native and denatured human ApoA1.
Dot Blot: Use on native and denatured human ApoA1.
Immunohistochemistry (Frozen): 1:40; Not tested on paraffin sections.
Immunocytochemistry: Cultured human cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
HostSheep
SourceHuman
ConcentrationNot determined.
FormSupplied as a lyophilized powder from PBS, mannitol. Reconstitute with 1ml sterile ddH2O.
PurityPurified by immunoaffinity chromatography.
ImmunogenHuman Apolipoprotein AI.
SpecificityRecognizes human Apolipoprotein AI (apoAI) at ~28kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAPOA1/APOC3 Fusion Gene


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