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You are here:Home » Antibodies » Abs to Lipoproteins » Anti -Apolipoprotein A-I (Apolipoprotein A-I Precursor, Apolipoprotein AI, Apo AI, Apo A-I, ApoA-I, Apo-AI, Apolipoprotein A1, APOA1, Ltw-1, Lvtw-1, MGC117399)

Anti -Apolipoprotein A-I (Apolipoprotein A-I Precursor, Apolipoprotein AI, Apo AI, Apo
A-I, ApoA-I, Apo-AI, Apolipoprotein A1, APOA1, Ltw-1, Lvtw-1, MGC117399)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B
Apolipoprotein AI promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein AI is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77aa; an 18aa signal peptide is removed co-translationally and a 6aa propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
Catalog #A2299-12R
ApplicationsSuitable for use in ELISA, Western Blot and Dot Blot. Other applications not tested.
Recommended DilutionELISA: 1:30,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.5, BSA, 50% glycerol.
PurityPurified
ImmunogenHuman apolipoprotein A1.
SpecificityRecognizes human apolipoprotein A1 and human HDL. Does not cross-react with human apolipoprotein B, LDL or VLDL. Does not cross-react with other human plasma proteins (albumin, immunoglobulins etc.).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAPOA1/APOC3 Fusion Gene


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