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You are here:Home » Antibodies » Abs to Lipoproteins » Anti -Apolipoprotein E (Apolipoprotein-E, Apo E, ApoE, Apo-E, Alzheimer Disease 2, AD2, Apolipoprotein E3, APOE3, Apoprotein, LDLCQ5, LPG, MGC1571)

Anti -Apolipoprotein E (Apolipoprotein-E, Apo E, ApoE, Apo-E, Alzheimer Disease 2, AD2,
Apolipoprotein E3, APOE3, Apoprotein, LDLCQ5, LPG, MGC1571)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E IH
Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are essential for the normal breakdown of these molecules. In particular, apolipoprotein E is a major component of specific lipoproteins called very low-density lipoproteins (VLDL). A major function of VLDLs is to remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular diseases, including heart attacks and strokes. Apolipoprotein E is a type of lipoprotein. Apolipoprotein E is associated with several cardiovascular disorders. There are three isoforms (slightly different forms) of the ApoE lipoprotein. These three isoforms are known as ApoE2, E3 and E4. ApoE2 seems to be one of several genetic factors that plays a part in increased risk of heart attacks and strokes and ApoE4 is a risk factor for coronary artery disease. As well, ApoE4 has been been suggested to play a role in type 2 Alzheimer’s disease.
Catalog #A2299-74C
ApplicationsSuitable for use in ELISA and Immunohistochemistry. For depletion experiments the antibody should be used in a solid phase system. Other applications not tested.
Recommended DilutionELISA: 1:1000
Immunohistochemistry (frozen): 1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No3D12
HostMouse
SourceHuman
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder. Reconstitute with 1ml sterile ddH2O.
PurityPurified by ammonium sulfate precipitation and DEAE chromatography.
ImmunogenHuman Apo-E from plasma
SpecificityRecognizes human Apo-E. Recognizes all alleles of Apo-E. Reacts with very low density lipoproteins (VLDL) of human plasma. Reacts as well with LDL as with VLDL. No crossreactions with other human plasma proteins are observed.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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