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You are here:Home » Antibodies » Antibodies-Lipoproteins » Anti -Apolipoprotein E (Apo E)

Anti -Apolipoprotein E (Apo E)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IH FC
Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are essential for the normal breakdown of these molecules. In particular, apolipoprotein E is a major component of specific lipoproteins called very low-density lipoproteins (VLDL). A major function of VLDLs is to remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular diseases, including heart attacks and strokes. Apolipoprotein E is a type of lipoprotein. Apolipoprotein E is associated with several cardiovascular disorders. There are three isoforms (slightly different forms) of the ApoE lipoprotein. These three isoforms are known as ApoE2, E3 and E4. ApoE2 seems to be one of several genetic factors that plays a part in increased risk of heart attacks and strokes and ApoE4 is a risk factor for coronary artery disease. As well, ApoE4 has been been suggested to play a role in type 2 Alzheimer disease.
Catalog #A2299-74D
ApplicationsSuitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsFlow Cytometry: 1ug/10e6 cells
ELISA: 1:100-1:2000
Western Blot: 2ug/ml. A band observed at ~36kD
Immunoprecipitation: 1:10-1:500
Immunohistochemistry: 1:50-1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No8B65
ConcentrationAs Reported
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide
PurityPurified by Protein G affinity chromatography.
ImmunogenPurified human ApoE
SpecificityRecognizes human Apolipoprotein E. Does not react with rat brain tissue. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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