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You are here:Home » Antibodies » Abs to Lipoproteins » Anti -Apolipoprotein E (Apolipoprotein-E, Apo E, ApoE, Apo-E, Alzheimer Disease 2, AD2, Apolipoprotein E3, APOE3, Apoprotein, LDLCQ5, LPG, MGC1571)

Anti -Apolipoprotein E (Apolipoprotein-E, Apo E, ApoE, Apo-E, Alzheimer Disease 2, AD2,
Apolipoprotein E3, APOE3, Apoprotein, LDLCQ5, LPG, MGC1571)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E IH IC
The apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular, apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL), which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors, such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2, E3, E4) have been identified, with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3).
Catalog #A2299-74K
ApplicationsSuitable for use in ELISA, Dot Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1000 on native and denatured human apoE.
Dot Blot: native and denatured human apoE.
Immunohistochemistry (Frozen): 1:30
Immunocytochemistry: Cultured human cells.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder. Reconstitute with 1ml sterile ddH2O.
PurityPurified
ImmunogenHuman Apolipoprotein E from plasma.
SpecificityRecognizes human Apolipoprotein E. Specificity is confirmed by derect ELISA with purified human apoE adsorbed to plastic wells, by Ouchterlony immunodiffusion, and by dot-blot assay with different fractions of lipoproteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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