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You are here:Home » Antibodies » Abs to Lipoproteins » Anti -Apolipoprotein E (ApoE)

Anti -Apolipoprotein E (ApoE)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Catalog #A2299-75C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000.
Western Blot: 0.1-0.3ug/ml. Predicted MW is 36.2kD according to NP_000032.1.
Optimal dilutions to be determined by the researcher..
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormTris saline containing 0.02% sodium azide, pH7.3 with 0.5% BSA
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide with sequence C-VGTSAAPVPSDNH, representing the C Terminus of the human protein according to NP_000032.1. Epitope: C Terminus
SpecificityThis antibody is specific for APOE Species Crossreactivity: Human, Chimpanzee
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAcetaldehyde dehydrogenase 1, AHD2, ALDC, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde Dehydrogenase, Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase family 1 member A1, Aldehyd


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