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Specifications

Clone Host Grade Applications Polyclonal Goat Affinity Purified E B

ApoE is a 35-40kD protein component of serum chylomicrons, VLDL, and HDL particles. It mediates the binding, uptake, and catabolism of these particles through interactions with the ApoE receptor and LDL receptors in the liver and brain. ApoE is important in fatty acid homeostasis and memory formation. Polymorphisms encode three variants (ApoE2, 3, 4) which are differentially related to the development of atherosclerosis and neurogenerative disorders. Mature human ApoE shares 71% aa sequence identity with mouse and rat ApoE.
Catalog #	A2299-76E
Applications	Suitable for use in ELISA, Western Blot, Enzyme Conjugation, or Biotinylation. Other applications not tested.
Recommended Dilution	ELISA: 1:200-1:80,000
	Western Blot: 1:200-1:80,000
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Host	Goat
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in 75mM sodium phosphate, 75mM sodium chloride, 0.5mM EDTA, pH 7.2, 0.02% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Purified human Apo E from human plasma.
Specificity	Recognizes human Apolipoprotein E (Apo E). Recognizes isoforms E2, E3 and E4.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.