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You are here:Home » Antibodies » Abs to Lipoproteins » Anti -Apolipoprotein E2 (Apo E2, APOE 2, APOE-2, APOE2, Apolipoprotein E, AD2)

Anti -Apolipoprotein E2 (Apo E2, APOE 2, APOE-2, APOE2, Apolipoprotein E, AD2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. ApoE2 is a 34.3kD protein containing 300 amino acid residues.
Catalog #A2299-76U
ApplicationsSuitable for use in Western Blot. Other applications have not been tested.
Recommended DilutionsWestern Blot: 0.5-4 ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control A2299-76K Apolipoprotein E2, Recombinant, Human
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight34.3kD
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% thimerosal, 30% glycerol.
PurityPurified by immunoaffinitiy chromatography.
ImmunogenE. coli expressed recombinant human ApoE2.
SpecificityRecognizes human Apo E2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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