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You are here:Home » Biochemicals » Biochem-Antibiotics » Apoptolidin



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Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene at an IC50 = 11 ng/ml. It is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.
Catalog #A2299-85
Purity >95% by HPLC
Solubility Soluble in ethanol, methanol, DMF or DMSO
Related to Isoapoptolidin
CAS Number194874-06-1
Molecular FormulaC58H96O21
Molecular Weight1129.37
SourceAmycolatopsis sp
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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