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Specifications

Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene at an IC50 = 11 ng/ml. It is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.
Catalog #	A2299-85
Purity	>95% by HPLC
Solubility	Soluble in ethanol, methanol, DMF or DMSO
Related to	Isoapoptolidin
CAS Number	194874-06-1
Molecular Formula	C58H96O21
Molecular Weight	1129.37
Source	Amycolatopsis sp
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.