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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -Apoptosis Antagonizing Transcription Factor (AATF, CHE1, CHE-1, DED, HSPC277, Protein AATF, Rb-binding Protein Che-1)

Anti -Apoptosis Antagonizing Transcription Factor (AATF, CHE1, CHE-1, DED, HSPC277,
Protein AATF, Rb-binding Protein Che-1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid -peptide and to inhibit aberrant production of the -peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer’s disease (AD), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.
Catalog #A2299-90R
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman small intestine cell
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRaised against a 12aa peptide from near the carboxy terminus of human AATF (NP_036270).
SpecificityRecognizes human AATF. Species Crossreactivity: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesApoptosis-antagonizing Transcription Factor


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