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Anti -AATF (Apoptosis antagonizing transcription factor CHE1, DED, HSPC277, Protein AATF, Rb-binding protein Che-1)
Anti -AATF (Apoptosis antagonizing transcription factor CHE1, DED, HSPC277, Protein
AATF, Rb-binding protein Che-1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
IH |
|
| Apoptosis Antagonizing Transcription Factor (AATF), also known as Che-1, is a ubiquitously expressed nuclear protein. Research indicates that AATF functions as a general inhibitor of the histone deacetylase HDAC1. It has been also demonstrated that AATF activates transcription factor E2F and that it is involved in the activation of anti-apoptotic pathways. AATF has been shown to protect neural cells against oxidative damage suggesting it may have therapeutic uses in Alzheimer's Disease. | | | Catalog # | A2299-90W | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 2.5ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human testis | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by ammonium sulfate precipitation. | | Immunogen | Synthetic peptide corresponding to a 12aa sequence near the C-terminus of human AATF. | | Specificity | Recognizes human AATF. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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