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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -AATF (Apoptosis antagonizing transcription factor CHE1, DED, HSPC277, Protein AATF, Rb-binding protein Che-1)

Anti -AATF (Apoptosis antagonizing transcription factor CHE1, DED, HSPC277, Protein
AATF, Rb-binding protein Che-1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified IH
Apoptosis Antagonizing Transcription Factor (AATF), also known as Che-1, is a ubiquitously expressed nuclear protein. Research indicates that AATF functions as a general inhibitor of the histone deacetylase HDAC1. It has been also demonstrated that AATF activates transcription factor E2F and that it is involved in the activation of anti-apoptotic pathways. AATF has been shown to protect neural cells against oxidative damage suggesting it may have therapeutic uses in Alzheimer's Disease.
Catalog #A2299-90W
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 2.5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman testis
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide corresponding to a 12aa sequence near the C-terminus of human AATF.
SpecificityRecognizes human AATF. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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