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You are here:Home » Antibodies » Abs to Apoptosis » Anti -APRIL, ED (a Proliferation Inducing Ligand, TALL-2, TNF and ApoL-related Leukocyte-expressed Ligand 2, TRDL-1a, TNF-related Death Ligand 1a, TNFSF13)

Anti -APRIL, ED (a Proliferation Inducing Ligand, TALL-2, TNF and ApoL-related
Leukocyte-expressed Ligand 2, TRDL-1a, TNF-related Death Ligand 1a, TNFSF13)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
APRIL (a proliferation inducing ligand) is a member of the TNF ligand superfamily. It is synthesized as a 32kD type II transmembrane protein which is cleaved by furin in the Golgi to release a 17kD soluble molecule. Secreted APRIL consists almost entirely of a single TNF homology domain. Little or no transmembrane APRIL is expressed on the cell surface. Alternate splicing generates isoforms with short deletions at the N- or C-terminus. Both APRIL and the closely related protein BAFF signal through the TNF superfamily receptors TACI and BCMA to promote cellular proliferation and protect from apoptosis. APRIL can form bioactive heterotrimers with BAFF. A bioactive cell surface-expressed protein known as TWEPRIL consists of the intracellular domain, transmembrane segment, and stalk region of TWEAK fused to the TNF homology domain of APRIL. Human APRIL shares 85% amino acid sequence identity with mouse and rat APRIL.
Catalog #A2299-98Z
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsELISA (capture): 2-8ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
IsotypeIgG2a
Clone No10F613
HostMouse
SourceHuman
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophillized powder from PBS, 5% trehalose. Reconstitute with 1ml sterile PBS.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant corresponding to aa110-250 from human APRIL expressed in NSO cells (Q8NFH7).
SpecificityRecognizes human APRIL. Does not crossreact with recombinant mouse APRIL or TWEAK or recombinant human BAFF, TWEAK, TACI or BCMA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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