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You are here:Home » Molecular Biology » MB-Apoptosis » APRIL, ED2, Blocking Peptide (a Proliferation Inducing Ligand, TALL-2, TNF and ApoL-related Leukocyte-expressed Ligand 2, TRDL-1a, TNF-related Death Ligand 1a, TNFSF13)

APRIL, ED2, Blocking Peptide (a Proliferation Inducing Ligand, TALL-2, TNF and
ApoL-related Leukocyte-expressed Ligand 2, TRDL-1a, TNF-related Death Ligand 1a, TNFSF13)

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Specifications

Synthetic peptide (CIRSMPSHPDRAYNS) corresponding to amino acids 196 to 210 of human APRIL (1-3).
Catalog #A2299-99P
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identi ed by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF-and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1a (for TNF related death ligand 1a) in human and mouse (1-4). Two receptors for APRIL were recently identi ed and designated TACI and BCMA (5-7). APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death (1-7). APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer (8,9).
Applications Suitable for use in ELISA and Western Blot. Other applications not tested.
Storage and Stability Lyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile 25% glycerol and store at -20°C. May be stored at 4°C for short-term only. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceSynthetic peptide
PurityPurified 60-70%
Concentration~0.2mg/ml
FormSupplied as a lyophilized powder.
Intended for research use only, not for use in human, therapeutic or diagnostic applications.


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