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Aprotinin, Bovine (Pancreatic trypsin inhibitor)
Aprotinin, Bovine (Pancreatic trypsin inhibitor)
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| Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins | | | Catalog # | A2300-03 | | Aprotinin is a natural proteinase inhibitor polypeptide consisting of 58 amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512D. | | Biological Activity | ~6000 KIU (Kallikrein Inactivator Units) per mg, 4.85 TIU/mg. | | Unit Definition | 1 Unit corresponds to 1 biological kallikrein inhibitor unit (KIU). | | 1 TIU ~1300 KIU. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, 0.1% HSA or BSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 9087-70-1 | | Source | Bovine lung | | Purity | 98% by RP-HPLC and SDS-PAGE. | | Concentration | ~0.1mg/ml | | Form | Supplied as a lyophilized powder. No additives. Reconstitute in sterile ddH2O, 0.1% HSA or BSA to a concentration > 0.1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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