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You are here:Home » Molecular Biology » MB-Protease Inhibitors » Aprotinin, Bovine (Pancreatic trypsin inhibitor)

Aprotinin, Bovine (Pancreatic trypsin inhibitor)

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Specifications

Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins
Catalog #A2300-03
Aprotinin is a natural proteinase inhibitor polypeptide consisting of 58 amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512D.
Biological Activity~6000 KIU (Kallikrein Inactivator Units) per mg, 3.47 TIU/mg.
Unit Definition1 Unit corresponds to 1 biological kallikrein inhibitor unit (KIU).
1 TIU ~1300 KIU.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O, 0.1% HSA or BSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number9087-70-1
Molecular Weight6512D
SourceBovine lung
Purity98% by RP-HPLC and SDS-PAGE
Concentration~0.1mg/ml
FormSupplied as a lyophilized powder. No additives. Reconstitute in sterile ddH2O, 0.1% HSA or BSA to a concentration > 0.1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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