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Aprotinin, Bovine (US/North America) (Pancreatic trypsin inhibitor)
Aprotinin, Bovine (US/North America) (Pancreatic trypsin inhibitor)
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| Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins. | | | Aprotinin is a natural proteinase inhibitor polypeptide consisting of 58 amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512D. | | | Catalog # | A2300-04 | | Solubility | Colorless, clear, complete | | Loss on drying: | | 2.0% | | Absorbance: | | 0.8 | | Histamine: | | 0.2ug/3EU | | Activity (on dried basis): | | 5400KIU/mg | | Protein impurities of higher molecular mass: Complies | | Bacterial endotooxins: None Detected | | Abnormal toxicity: Non-toxic | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 9087-70-1 | | Source | Bovine lung | | Form | Supplied as a white powder. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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