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You are here:Home » Molecular Biology » MB-Protease Inhibitors » Aprotinin, Recombinant, Bovine (Pancreatic Trypsin Inhibitor)

Aprotinin, Recombinant, Bovine (Pancreatic Trypsin Inhibitor)

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Specifications

Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung. It inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins (e.g., CD11b).
Catalog #A2300-07
Recombinant Bovine Aprotinin is approximately 6.51kD highly purified and designed specifically for cell culture applications, protein purification, diagnostic testing and pharmaceuticals. It is produced without the use of animal- or human-derived materials and is therefore free from risk of contaminating human or animal-derived viruses or prions.
Biological Activity~4.6 TIU/mg
Unit DefenitionOne Trypsin Inhibitory Unit (TIU) is equal to the amount of inhibitor with the ability to inhibit two trypsin units by 50% where one trypsin unit will hydrolyze 1.0 µmole of N-alpha-benzoyl-DL-Arginine-p-Nitroanilide (BAPNA) per minute at pH 7.8 at 25°C.
Storage and StabilityLyophilized powder may be stored at 4°C. Stable for 12 months at 4ºC. Reconstitute with sterile ddH2O. Aliquot and store at 4°C. Do not freeze. Stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight6.51kD
SourceMaize (Corn)
Purity~90% (SDS-PAGE)
ConcentrationAs reported
FormSupplied as a lyophilized powder. No additives. Reconstitute with sterile ddH2O to a concentration of 100ug/ml, which can then be further diluted to other aqueous solutions.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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