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You are here:Home » Antibodies » Abs to Aquaporin » Anti -Aquaporin 8

Anti -Aquaporin 8

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein “aquaporin”.
A new water channel, AQP8, has been identified in rat pancreas and testis by homology cloning. AQP8 (263aa; 28kD) is also found in liver, colon and salivary glands. AQP8 is expressed in all stages of spermatogenesis. Unlike other AQP, AQP8 has unusually long N-terminus and a short C-terminus. AQP families of proteins are predicted to contain six transmembrane domains. The N and C-terminus are predicted to be cytoplasmic. AQP8 has significant homology to various AQPs: g-TIP (plant water channel, 37%); AQP2 and MIP (37%), AQP1, AQP4, and AQP5 (30-34%); AQP3 (26%). AQP8 does not facilitate glycerol transport.
Catalog #A3000-36A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000-1:5000 using ECL.
ELISA: 1:10,000-50,000. Control peptide can be used to coat plates at 1ug/ml.
Optimal dilutions to be determined by the researcher.
Control PeptideA3000-36F: Aquaporin 8, Rat, Control Peptide (AQP8)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot Determined
FormSupplied as a liquid in PBS, 0.05% sodium azide
PuritySerum
ImmunogenSynthetic peptide corresponding to 16aa near the C-terminal , cytoplasmic domain of rat AQP8.
Species Sequence HomologyMouse
SpecificityRecognizes rat AQP8.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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