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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum E B

Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. AQP0 or MIP26 (major intrinsic protein 26kD), and Aquaporin-1 (AQP1, purified from red cells) also called CHIP-28 (channel forming integral protein, 28kD; 268aa; gene locus 7p14) has been the foundation of the growing family of aquaporin. The lens specific AQP0 represents up to 80% of total lens membrane protein. Defects in MIP26 are cause of autosomal dominant cataract.
Catalog #	A3000-45
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilutions	Western Blot:1:1000-1:5000 (ECL).
	ELISA: 1:100,000. Control peptide can be used to coat ELISA plates at 50-100ng/well.
	Optimal dilutions to be determined by the researcher.
Recommended Control Peptide	A3000-55: Aquaporin 9, Rat, Control Peptide (AQP9)
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Rat
Concentration	Not Determined
Form	Supplied as a liquid in PBS, 0.05% sodium azide.
Purity	Serum
Immunogen	Synthetic peptide corresponding to 18aa within the C-terminal cytoplasmic domain of rat AQP9, conjugated to KLH. Species Sequence Homology: mouse; 94%; human; 72%.
Specificity	Recognizes rat Aquaporin 9.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.