You are here:Home
»
Lectins
»
Lectin-Arachis hypogaea
»
Arachis hypogaea (PNA, Peanut Agglutinin) (Biotin)
Arachis hypogaea (PNA, Peanut Agglutinin) (Biotin)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Lectins are derived from the extracts of plants, animals, viruses and microorganisms. They are known to agglutinate red blood cells. These agglutinins can select cell types according to blood group activities utilizing sugar-binding mechanisms. | | | Catalog # | A3305-15 | | Lectins form precipitates with glycoconjugates. They are useful for identifying or separating oligosaccharides with identical sugar compositions such as galactose, mannose or glucose. | | Arachis hypogaea (PNA, Peanut Agglutinin), 110kD, is composed of four identical subunits of ~27kD each. It is galactose-specific, with strong anti-T-antigen activity. T-antigen is present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. PNA does not agglutinate normal human erythrocytes. It strongly agglutinates neuraminidase-treated red blood cells. The presence of Ca2+ can enhance the binding of PNA to receptors. Asialo GM1 ganglioside is also thought to be a major cell surface receptor for PNA. PNA is useful in normal and tumor tissue determination for transitional mucosa malignancies. | | Carbohydrate Specificity | Terminal b-galactose | | Inhibitory Carbohydrate | Lactose > b-galactose | | Activity | < 1ug/ml will agglutinate human erythrocytes neuraminidase treatment of cells. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | N/A | | Molecular Weight | 120kD | | Source | Peanut | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.3. Labeled with biotinyl N-hydroxysuccinimide ester (BNOHSE). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | peanut |
External Links
|
