Anti -ARAP1 (Arf-GAP with Rho-GAP Domain, ANK Repeat and PH Domain-containing Protein 1,
Centaurin-delta-2, Cnt-d2, CENTD2, KIAA0782)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B IC |
|
| ARAP1 is a 1450aa containing signaling protein, belonging to the centaurin family with SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, ARAP1 displays RHO-GAP and phosphatidylinositol (3, 4, 5) trisphosphate (PIP3)-dependent ARF-GAP activity that regulates ARF-, RHO-, and CDC42-dependent cell activities. It associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thus involved in both signal transduction and cellular trafficking transport of a receptor protein involved in apoptosis. This protein is likely involved in the regulation of the cell-specific trafficking of TNFRSF10A and might thus affect the efficacy of TRAIL-induced apoptosis. ARAP1, an adaptor protein, is ubiquitously expressed in most of the tissues. | | | Catalog # | A3309-02 | | Applications | Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 1:32,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-AFTADPLSLLRNV, from mouse ARAP1, at C-terminal (NP_056057.2, NP_001035207.1, NP_001128662.1). | | Specificity | Recognizes mouse ARAP1. Species sequence homology: Bovine, canine, human, porcine and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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