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You are here:Home » Antibodies » Abs to Golgi Proteins » Anti -ARAP3 (Arf-GAP with Rho-GAP Domain, ANK Repeat and PH Domain-containing Protein 3, Centaurin-delta-3, Cnt-d3, CENTD3)

Anti -ARAP3 (Arf-GAP with Rho-GAP Domain, ANK Repeat and PH Domain-containing Protein 3,
Centaurin-delta-3, Cnt-d3, CENTD3)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IP
ARAP3, also known as Centaurin-delta-3, is a protein with an Arf-GAP domain, three PH domains, a Ras-associating domain, a Rho-GAP domain and a SAM (sterile alpha motif) domain. ARAP3 is a phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. It is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. ARAP3 acts on ARF6, RAC1, RHOA and CDC42 and also plays a role in the internalization of anthrax toxin.
Catalog #A3309-10E
ApplicationsSuitable for use in ELISA, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:4000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to CTSSPPSSQPLT, from CENTD3, at C-terminal (NP_071926.4).
SpecificityRecognizes CENTD3. Species sequence homology: Bovine, canine, human, mouse and porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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