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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).
Catalog #	A3325-01
This polyclonal antibody can be used for detection of ARC by Western blot at 1	500 dilution. Whole cell lysate from HeLa cells can be used as positive control and an approximately 25kD band can be detected. It is human, mouse, and rat reactive.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	0.5mg/ml
Form	Supplied as a liquid in PBS, 0.02% sodium azide.
Purity	Immunoaffinity purified IgG
Immunogen	Peptide corresponding to amino acids 2 to 18 of human origin (1).
Specificity	Recognizes human, mouse and rat ARC (NT)
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.