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You are here:Home » Antibodies » Abs to Apoptosis » Anti -ARC (NT)

Anti -ARC (NT)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and 8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).
Catalog #A3325-01
This polyclonal antibody can be used for detection of ARC by Western blot at 1500 dilution. Whole cell lysate from HeLa cells can be used as positive control and an approximately 25kD band can be detected. It is human, mouse, and rat reactive.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityImmunoaffinity purified IgG
ImmunogenPeptide corresponding to amino acids 2 to 18 of human origin (1).
SpecificityRecognizes human, mouse and rat ARC (NT)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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