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You are here:Home » Antibodies » Abs to Apoptosis » Anti -ARC (Apoptosis Repressor with CARD, FLJ35304, Muscle-enriched Cytoplasmic Protein, Myp, Nucleolar Protein 3, NOL3, Nucleolar Protein of 30kD, Nop30, NOP)

Anti -ARC (Apoptosis Repressor with CARD, FLJ35304, Muscle-enriched Cytoplasmic Protein,
Myp, Nucleolar Protein 3, NOL3, Nucleolar Protein of 30kD, Nop30, NOP)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
ARC (apoptosis repressor with CARD), is also known as nucleolar protein 3. Apoptosis is regulated by molecules containing death domains or caspase recruitment domains (CARD). ARC contains a CARD domain, interacts with caspase­2 and interacts with and inhibits the activity of caspase­8. ARC suppresses apoptosis induced by the cell death receptors Fas, TNFR­1 and DR3 and by the cell death adapters FADD and TRADD. It is highly expressed in heart and skeletal tissue and found in low levels in placenta, kidney, liver and pancreas.
Catalog #A3325-01H
ApplicationsSuitable for use in Immunohistochemistry and Western Blot. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry (paraffin): 5ug/ml. Does not require protein digestion pre­treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Western Blot: 1:1000. Detects a band of ~24kD in A549 cell lysate
Optimal dilutions to be determined by the researcher.
Immunohistochemistry Positive ControlHuman skeletal muscle or heart tissue
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa191-208 of human ARC.
SpecificityRecognises human ARC (apoptosis repressor with CARD).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesNucleolar Protein 3 (Apoptosis Repressor with CARD Domain)


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