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Specifications

Peptide corresponding to amino acids 2 to 18 of human origin (1).
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).
Catalog #	A3325-01P
Source	Synthetic peptide
Purity	Purified 60-70%
Concentration	0.2mg/ml
Form	Supplied as a lyophilized powder.
Important Note	This product is intended for research use only, not for use in human, therapeutic or diagnostic applications.